Carotid Stenosis (Build up of atheroisclerosis or blockage in the neck arteries): This study is for patients that have a narrowing of the artery in their neck that would be suitable for treatment with a technique called stent implantation (slender tube that props the artery open). The purpose of this study is to determine the safety and effectiveness of using the stent with a protection device designed to capture material (plaque) that could break off from the narrowed are during the procedure.

Coronary Artery Disease: This study is evaluating an experimental "Blood thinning" drug in patients who would normally receive heparin to prevent blood clots for accurate coronary syndrome. Acute coronary syndrome is usually caused by a clot forming on a break in the inner lining of a coronary artery.

Coronary Artery Disease: The purpose of this study is to determine whether gene therapy using an investigational procedure can stimulate growth of new blood vessels in the heart and can be effective at relieving chest pain for patients with angina pectoris.

Congestive Heart Failure: This study will evaluate a new potential group of diuretics (water pills) safety, how well it is tolerated, and if it does a better job than currently used diuretics in controlling the patient’s congestive heart failure symptoms without causing mineral (sodium) imbalances in the blood.

Congestive Heart Failure Following a Heart Attack: The purpose of this study is to determine whether one medication is more effective or at least as effective and better tolerated as a proven medication, in improving the survival of people who suffer from heart failure after having a heart attack.

Congestive Heart Failure: The purpose of this study is to determine in patients with congestive heart failure whether one medicine is superior to placebo in reducing death and cardiovascular complications.

Coronary Artery Disease: The purpose of this study is to determine if the investigational covered stent is more effective in reducing restonosis (reocclusion) in the vein graft for patient that need a stent in a bypass vein graft.

Coronary Artery Bypass Graft Surgery: The purpose of this study is to determine whether a new medication can reduce side effects that are associated with heart bypass surgery such as chest pain, heart attacks, heart failure, or impairment of memory, language and motor skills.

Erectile Dysfunction: This study will evaluate the effectiveness and safety of a FDA approved medication that is currently used to treat erectile dysfunction in patients with congestive heart failure.

Heart Failure: This study will evaluate the effectiveness of the study medication compared with placebo in patients with extreme chronic heart failure.

Hyperlipidemia: This study will compare two medications, which are currently approved by the FDA and used to treat high cholesterol levels ( a known risk factor for heart diseases). The purpose of this study is to evaluate how safe and how well subjects tolerate higher does of these medications. The study will also monitor how well each medication controls cholesterol levels.

Hypertension: This is a clinical trial comparing the effectiveness of two cardiac medications for the treatment of high blood pressure and type II diabetes (non-insulin dependent diabetes).

Peripheral Artery Disease: The purpose of this study is to compare how safe and well tolerated a one-time dose of the study drug, FGF, is compared to placebo (no medicine) in improving the claudication symptoms (leg cramping) in patients with sever, disabling peripheral artery disease (blockages in the legs). The purpose of the study medicine is to stimulate the growth of blood vessels (arteries) in the legs. This process is known as angiogenesis, "growth of new vessels."

Peripheral Artery Disease: This study is for patients that have blockage in the arteries in their leg. The study is designed to compare the safety and effectiveness of the combination of a study drug and laser light treatment with balloon angioplasty at the blockage site, to decrease the chance of the blockages coming back (restenosis).

Peripheral Artery Disease: The purpose of this study is to evaluate the safety and effectiveness of a study medication in patients with severe peripheral artery disease (blockages of the arteries in the leg).